I shoot a Nikon D1x in Jpeg fine mode (5.9 megapixels image) 1998 Adobe mode.
I routinely crop the image in photoshop to 11x14 format, thus losing about 25 percent of the original image to the crop. I use the crop tool in photoshop set to 300 dpi which of course interpolates the image some.
I then apply a little sharpening and a little unsharp mask and have them printed at my local camera store by saving them to c.d. and then uploading them on their machine.
Unless you are looking at them with a loupe, you would not know they are digital, and anyone that says 35 mm makes a better 11x14 on average is some kind of miracle worker.
I see no pixelation.
I have also printed crops at 13x19 on an epson 1280 without noticeable pixelation.
I am sure that some "expert" can give me 10 reasons why 35mm is supposed to give a better print because a 35mm negative is supposed to be like the equivalent of a 20 megapixel sensor, but all I know is that I have had 11x14 prints made from negatives and I have been happier with my digital enlargments than I ever was with my 35 mm enlargements.
My camera store has 20x30 samples from an old Canon D30 that look wonderful. What program they may have used to interpolate, I don't know.
My biggest "learning curve" with digital hasn't been avoiding pixelation, but getting my monitor to match my output. In the last 6 months though, I have gotten that nailed and couldn't be happier.
For all those guys dreaming about a D1x or some other hot rod digital camera, be prepared for some mighty headaches trying to get your color output correct. It isn't that it can't be done, but it just takes a lot of time to figure out what to do to make the prints look good.
Levels, curves, unsharpmask, layering...all need to be learned.
I still shoot film and will admit that there is a certain "quality" to film that I don't think digital has quite got yet and may never get.
I have yet to get a digital black and white to come anywhere close to what I can get with good old film, even the chromogenic C-41 process stuff.
That's why there has been a couple of guys on here of late who have switched back to film and sold their digitals.
Film still has advantages.
Yes, digital is the future, but that doesn't mean it can't peacfully co-exist right along side digital.
Why some people make it an either/or proprosition I will never understand.
Seems to me it is sort of like arguing over chocolate versus regular milk, as if you can't have both.