The 2450 works fine w/9.2.2, as you mentioned, and there's a driver for Jaguar on a site linked from the Epson USA website. You have to look around for it, click a few times. Works great, better than the driver for 9.2, and easier to use than VueScan, in my opinion.
My 2450 sometimes has problems scanning silver-based B&W film, truncating the scans prematurely. It doesn't happen often, but only on images you really, really want. Same problem, same frequency w/Kodachrome. I've tried turning the negs, moving them in the holders, even physically inverting them or scanning as positives -- eventually something usually works. If not, the SilverFast prog. included w/the scanner will do the trick, but it works only in OS 9.2 (at least mine does).
Otherwise the scanner is fine, esp. w/med. format.
Sample 2450 scanned image