TIFF files can also hold 12 and 16 bit per color files (36 & 48 bits per pixel) and they can hold data which is compressed by a number of losless methods as well as lossy methings such as JPEG. Not all applications can understand all of the tags in a tiff file, therefore it's cross-platform/cross-application usefulness is waning.
JPEG files are 8 color bits per pixel only. If your camera can capture in 10 or 12 bit color, you'll loose color information by saving as a JPEG. Then you'll loose more stuff during the compression. It takes a keen eye or lots of compression to notice the loss however.
Finally, there is no guarentee that a CCD-RAW file MUST be smaller than a TIFF, although it usually is.
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