it depends on your penstroke length. i have a 4x5, and i tried a 6x8 and it was just way too big an area to cover for me. it really depends on how big your hand movements are when you're using the pen.
also take into account HOW you edit or retouch. i usually retouch at 400-600%, sometimes more, so i really don't need a large area to cover.
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